Related Experiment Video

Updated: Jul 20, 2026

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease

Fumiyuki Otsuka1, Seigo Sugiyama, Sunao Kojima

  • 1Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan.

Journal of the American College of Cardiology
|September 19, 2006
PubMed

Insights

Low plasma adiponectin levels are linked to complex coronary lesions in men with coronary artery disease (CAD). This suggests adiponectin may play a role in coronary plaque vulnerability.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Biomarkers

Background:

  • Metabolic disorders like diabetes increase cardiovascular event risk.
  • Adiponectin, a key metabolic molecule, has anti-atherogenic properties.
  • Low adiponectin is linked to coronary artery disease (CAD) and myocardial infarction, but its role in plaque vulnerability is unclear.

Purpose of the Study:

  • To determine if plasma adiponectin levels correlate with the complexity of coronary lesions in patients with CAD.
  • To investigate the association between adiponectin and coronary plaque vulnerability.

Main Methods:

  • Plasma adiponectin levels were measured in 207 men with stable CAD or acute coronary syndromes (ACS).
  • Coronary lesions were angiographically classified as simple or complex.
  • Statistical analyses included logistic regression to assess independent associations.

Main Results:

  • Stable CAD patients with complex lesions had significantly lower adiponectin levels than those with simple lesions.
  • Adiponectin levels were independently associated with coronary lesion complexity.
  • In ACS patients, lower adiponectin levels were observed in those with multiple complex lesions compared to single complex lesions.

Conclusions:

  • Plasma adiponectin levels are significantly associated with coronary lesion complexity in men with CAD.
  • Lower adiponectin levels may indicate increased coronary plaque vulnerability.
Abstract

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...