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Updated: Jul 20, 2026
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Application of the EMIT 2000 Tacrolimus assay on the Abbott Architect c8000 high volume clinical chemistry analyzer
Klas Boer1, Thomas Deufel, Dirk Schmidt
1Institut fur Klinische Chemie und Labordiagnostik FSU Jena, Germany. kboeer@med.uni-jena.de
Objectives:
Evaluation of the performance of the EMIT 2000 Tacrolimus assay on the Abbott Architect c8000 analyzer.
Design And Methods:
Imprecision studies were performed and patient samples were assayed by EMIT assay and by LC-MS/MS.
Results:
Limit of quantification was established at 2.8 microg/L. A positive bias of 17.5% between results measured on EMIT and on LC-MS/MS was detected.
Conclusions:
EMIT 2000 Tacrolimus assay is suitable for automated analyses of Tacrolimus on the Architect c8000.
