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Updated: Jul 20, 2026
Single Oocyte Bisulfite Mutagenesis
Published on: June 27, 2012
No differences in the DNA methylation pattern in mouse zygotes produced in vivo, in vitro, or by intracytoplasmic
1Department of Cell Ultrastructure and Molecular Biology, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.
Abstract:
The pattern and degree of pronuclear DNA methylation has been evaluated in naturally, in in vitro, or in intracytoplasmic sperm injection (ICSI)-produced mouse embryos. The results show no differences between all experimental groups and confirm the relative safety of IVF and ICSI.
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