Image registration and data fusion in radiation therapy

This paper provides an overview of image registration and data fusion techniques used in radiation therapy, and examples of their use. They are used at all stages of the patient management process; for initial diagnosis and staging, during treatment planning and delivery, and after therapy to help monitor the patients' response to treatment. Most treatment planning systems now support some form of interactive or automated image registration and provide tools for mapping information, such as tissue outlines and computed dose from one imaging study to another. To complement this, modern treatment delivery systems offer means for acquiring and registering 2D and 3D image data at the treatment unit to aid patient setup. Techniques for adapting and customizing treatments during the course of therapy using 3D and 4D anatomic and functional imaging data are currently being introduced into the clinic. These techniques require sophisticated image registration and data fusion technology to accumulate properly the delivered dose and to analyse possible physiological and anatomical changes during treatment. Finally, the correlation of radiological changes after therapy with delivered dose also requires the use of image registration and fusion techniques.