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08:34
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
[Hormone therapy for breast cancer]
Hidetaka Uramoto1, Seiji Kagami, Atsushi Iwashige
1Cancer Chemotherapy Center University Hospital, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Journal of UOEH
|September 20, 2006
Summary
Endocrine therapy for breast cancer blocks estrogen action. This review covers luteinizing hormone-releasing hormone agonists, aromatase inhibitors, tamoxifen, and medroxyprogesterone acetate based on clinical trials.
Area of Science:
- Oncology
- Endocrinology
- Pharmacology
Context:
- Breast cancer proliferation is often driven by estrogen.
- Estrogen receptor signaling promotes tumor growth.
- Endocrine therapy aims to counteract estrogen's effects.
Purpose:
- To review current endocrine therapy strategies for breast cancer.
- To discuss the mechanisms of action for various endocrine agents.
- To highlight findings from recent clinical trials in breast cancer endocrine therapy.
Summary:
- Breast cancer's growth is linked to estrogen and estrogen receptor activity.
- Endocrine therapies target estrogen supply or receptor interaction.
- Agents include luteinizing hormone-releasing hormone agonists, aromatase inhibitors, tamoxifen, and medroxyprogesterone acetate.
Impact:
- Provides an overview of endocrine therapy options for breast cancer.
- Informs clinical decision-making based on recent evidence.
- Contributes to understanding hormone-responsive breast cancer treatment.
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