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Updated: Jul 20, 2026
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Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
Published on: August 31, 2015
Tigecycline: a glycylcycline antimicrobial agent
Thien-Ly Doan1, Horatio B Fung2, Dhara Mehta3
1Pharmacy Department, Long Island Jewish Medical Center, New Hyde Park, New York, USA.
Clinical Therapeutics
|September 20, 2006
Summary
Tigecycline is an effective antibiotic for complicated skin and abdominal infections, including those caused by multidrug-resistant bacteria. It is generally well-tolerated, with gastrointestinal issues being the most common side effect.
Area of Science:
- Pharmacology
- Infectious Diseases
- Microbiology
Background:
- Tigecycline is the first approved glycylcycline antibiotic, designed to overcome tetracycline resistance mechanisms.
- It is indicated for complicated skin and skin-structure infections and complicated intra-abdominal infections via intravenous administration.
Purpose of the Study:
- To summarize the in vitro and in vivo activities of tigecycline.
- To review its pharmacologic, pharmacokinetic, clinical efficacy, and tolerability profile.
Main Methods:
- Literature search of MEDLINE, Iowa Drug Information Service, and International Pharmaceutical Abstracts.
- Review of conference abstracts and manufacturer-provided documents.
Main Results:
- Tigecycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
- Demonstrates in vitro activity against a broad spectrum of bacteria, including multidrug-resistant strains.
- Phase III trials showed noninferior efficacy compared to vancomycin/aztreonam and imipenem/cilastatin for indicated infections, with cure rates over 80%.
Conclusions:
- Tigecycline is effective for treating complicated skin and abdominal infections.
- Generally well-tolerated, with gastrointestinal adverse events being most common.
- Its broad spectrum, including activity against multidrug-resistant pathogens, makes it a valuable treatment option.
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