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Published on: July 20, 2022
Continuous ambulatory peritoneal dialysis is effective for patients with severe congestive heart failure
Hiroshi Takane1, Hidetomo Nakamoto, Hiroshi Arima
1Saitama Medical School, Japan.
Insights
Continuous ambulatory peritoneal dialysis (CAPD) significantly improves cardiac function and symptoms in patients with refractory heart failure. This treatment option enhances left ventricular ejection fraction and blood pressure control, offering a viable solution for combined heart and kidney conditions.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Background:
- Refractory heart failure often coexists with chronic renal insufficiency.
- Continuous ambulatory peritoneal dialysis (CAPD) is an established renal replacement therapy.
Purpose of the Study:
- To evaluate the efficacy of CAPD as an adjunctive therapy for symptomatic congestive heart failure patients with chronic renal insufficiency.
Main Methods:
- Sixteen patients (13 male, 3 female) with symptomatic congestive heart failure and chronic renal insufficiency were initiated on CAPD.
- Left ventricular ejection fraction (LVEF) and New York Heart Association (NYHA) functional classification were assessed before and after CAPD initiation.
Main Results:
- CAPD treatment led to a significant improvement in mean LVEF from 31% to 44% (p < 0.05) after one year.
- Eighty-seven percent of patients improved to NYHA grade I or II within one year.
- Significant improvements in blood pressure control were also observed.
Conclusions:
- CAPD, in conjunction with standard medical treatment, offers significant benefits for patients with combined congestive heart failure and chronic renal insufficiency.
- CAPD demonstrates potential as a preferred treatment modality for this patient population, improving both cardiac function and quality of life.
Abstract:
Although the use of continuous ambulatory peritoneal dialysis (CAPD) to treat refractory heart failure is not new, in combination with current medical treatment it improves patients'symptoms as well as their cardiac function. We started 16 patients (13 men with a mean age of 66.3 +/- 2.8 years, and 3 women with a mean age of 72 +/- 4.2 years) on CAPD. All patients were symptomatic with congestive heart failure. Mean left ventricular ejection fraction (LVEF) before the start of CAPD was 31% +/- 3%. Introduction to CAPD was associated with a significant improvement in LVEF (to 44% +/- 6%, p < 0.05) and in blood pressure control at 1 year. Also at 1 year, 87% of patients were classified as New York Heart Association grade I or II (maximum possible grade is grade III). These results suggest that CAPD is a treatment of choice for patients suffering from a combination of congestive heart failure and chronic renal insufficiency.
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Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...