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Related Experiment Videos

Multiple tumor types may originate from bone marrow-derived cells.

Chunfang Liu1, Zhongwei Chen, Zhihong Chen

  • 1Center of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Neoplasia (New York, N.Y.)
|September 21, 2006
PubMed
Summary

Bone marrow-derived cells (BMDCs) can transform into various tumor types, including teratomas. These findings suggest that malignant BMDCs may be a source of multipotent cancer stem cells.

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Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Research

Background:

  • Traditionally, tumors were thought to arise from tissue-specific stem cells.
  • Bone marrow-derived cells (BMDCs) exhibit plasticity and can reside in various tissues, suggesting a potential role in malignancy.
  • The plasticity of BMDCs raises questions about their contribution to diverse tumor origins.

Purpose of the Study:

  • To investigate if bone marrow-derived cells (BMDCs) can serve as a source for various tumor types.
  • To determine the potential of transformed BMDCs to form different cancers and exhibit cancer stem cell characteristics.

Main Methods:

  • Bone marrow-derived cells (BMDCs) from mice were isolated and treated with 3-methylcholanthrene to induce malignant transformation.
  • The transformed BMDCs were analyzed in vivo and in vitro for their tumor-forming capabilities and stem cell markers.

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  • Assays included assessing tumor formation in vivo and self-renewal/differentiation potential in vitro.

    • Main Results:

    • Transformed BMDCs generated a wide array of tumor types in vivo, including epithelial, neural, muscular, fibroblast, and endothelial tumors, as well as poorly differentiated tumors.
    • A single transformed BMDC demonstrated self-renewal and spontaneous differentiation into diverse tumor cell types in vitro.
    • Transformed BMDCs expressed markers associated with multipotency and formed teratomas in vivo.

    Conclusions:

    • Transformed bone marrow-derived cells (BMDCs) can give rise to multiple tumor types, challenging the traditional view of tumor origins.
    • These findings indicate that multipotent cancer stem cells may originate from malignant transformations of BMDCs.
    • BMDCs represent a potential source for various cancers, including teratomas, and highlight their role in cancer development.