Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Invasive candidiasis.

Peter G Pappas1

  • 1Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, AL 35294-0006, USA. pappas@uab.edu

Infectious Disease Clinics of North America
|September 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidemiology and Clinical Features of Cryptococcosis Among Individuals Without HIV Infection: An Observational International Multicenter Study (MSG-11).

Open forum infectious diseases·2026
Same author

Exploring Early Antifungal Activity of Rezafungin as a Stepping-Stone for Shorter Treatment Duration for Candidemia: Pooled Analysis of 2 Randomized Trials.

Open forum infectious diseases·2026
Same author

Development Framework of Desirability of Outcome Ranking Endpoints for Use in Clinical Trials of Invasive Fungal Diseases.

Open forum infectious diseases·2026
Same author

Rezafungin Versus Caspofungin for the Treatment of Candidemia and Invasive Candidiasis: Results from the Double-blind, Randomized, Phase 3 ReSTORE Trial Including the China Extension Study.

Open forum infectious diseases·2025
Same author

Histopathologic Insights Into Curvularia-Induced Chronic Granulomatous Fungal Sinusitis: A Guide for Surgical Pathologists.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2025
Same author

COVID-19-associated Pulmonary Aspergillosis in Mechanically Ventilated Patients at 7 US Hospitals: Epidemiology and Estimated Likelihood of Invasive Pulmonary Aspergillosis-Results of the Prospective MSG-017 Study.

Open forum infectious diseases·2025
Same journal

Prevention and Control of Clostridioides difficile Infection for the Infectious Diseases Clinician.

Infectious disease clinics of North America·2026
Same journal

Infection Control Strategies to Prevent Emergence and Transmission of Resistant Gram-Negative Bacteria.

Infectious disease clinics of North America·2026
Same journal

Preventing the Spread of Tuberculosis in Health Care Settings.

Infectious disease clinics of North America·2026
Same journal

Threats to Success: Principles of Infection Prevention and Control in Health Care Settings, Part 2: Device and Pathogen Management.

Infectious disease clinics of North America·2026
Same journal

Ventilator-Associated Events: Surveillance and Prevention.

Infectious disease clinics of North America·2026
Same journal

Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Prevention of Candida and Other Yeasts.

Infectious disease clinics of North America·2026
See all related articles

Invasive candidiasis (IC) diagnosis and treatment present challenges. Improved diagnostics and tailored therapies, especially for non-albicans Candida, are crucial for better patient outcomes in this evolving nosocomial infection.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Hospital Epidemiology

Background:

  • Invasive candidiasis (IC) is a significant nosocomial infection with persistent diagnostic and therapeutic hurdles.
  • Epidemiological shifts in IC are influenced by increased use of antifungal prophylaxis, broad-spectrum antibiotics, and indwelling medical devices.
  • Current diagnostic methods for IC often lack sensitivity, delaying critical early interventions.

Purpose of the Study:

  • To highlight the unmet needs in the diagnosis and management of invasive candidiasis.
  • To emphasize the necessity for enhanced diagnostic tools for earlier detection of IC.
  • To call for further research into optimal treatment strategies for candidemia and non-albicans Candida infections.

Main Methods:

  • Review of current literature on invasive candidiasis epidemiology, diagnostics, and therapeutics.

Related Experiment Videos

  • Analysis of challenges in clinical practice related to patient risk stratification and prevention.
  • Identification of research gaps in understanding and managing IC.

    • Main Results:

    • Diagnosis of IC remains challenging, necessitating improved tools for timely intervention.
    • Emerging antifungal agents show promise, but their optimal use, particularly for non-albicans species, requires further investigation.
    • Lack of a consistent approach to treatment and prevention for high-risk individuals persists despite known risk factors and mortality.

    Conclusions:

    • There is a critical need for advanced diagnostic modalities to facilitate earlier diagnosis and treatment of invasive candidiasis.
    • Further research is essential to optimize the use of newer antifungal agents and develop standardized prevention strategies for high-risk populations.
    • Addressing these clinical research areas is vital for improving the management of this common and evolving nosocomial infection.