Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proton RBE for in vivo model systems: LET and dose dependencies for early and late biological endpoints.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

Dual-time-point [<sup>18</sup>F]FDG-PET/CT as a prognostic biomarker in patients with pleural mesothelioma undergoing immunotherapy.

EJNMMI research·2026
Same author

Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: The Phase 2 DOREMY Nonrandomized Clinical Trial.

JAMA oncology·2026
Same author

Cell survival and DNA damage along the distal edge of the proton Bragg peak.

International journal of radiation biology·2026
Same author

Direct integration of deep learning-based GTV auto-segmentation into a clinical radiotherapy planning system.

Physics and imaging in radiation oncology·2026
Same author

Geometry-based framework for beam angle selection in proton therapy for lung cancer.

Physics and imaging in radiation oncology·2026

Related Experiment Video

Updated: Jul 19, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Adapting radiotherapy to hypoxic tumours.

Eirik Malinen1, Aste Søvik, Dimitre Hristov

  • 1Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway. eirik.malinen@fys.uio.no

Physics in Medicine and Biology
|September 21, 2006
PubMed
Summary

Biologically adapted radiotherapy using hypoxia imaging and intensity modulated radiotherapy (IMRT) significantly improves tumor control probability (TCP). This approach, involving dose redistribution for hypoxic tumors, offers a fourfold increase in optimal TCP compared to uniform dosing.

More Related Videos

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

Related Experiment Videos

Last Updated: Jul 19, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

Area of Science:

  • Radiation oncology
  • Medical imaging
  • Computational biology

Background:

  • Hypoxic tumors pose challenges in radiotherapy due to their resistance to treatment.
  • Functional tumor imaging can identify hypoxic regions for targeted therapy.

Purpose of the Study:

  • To investigate the potential of biologically adapted radiotherapy for hypoxic tumors.
  • To evaluate the efficacy of dose redistribution using intensity modulated radiotherapy (IMRT) based on hypoxia imaging.

Main Methods:

  • Dynamic contrast-enhanced magnetic resonance imaging (DCEMRI) was used to assess tumor hypoxia in a canine sarcoma model.
  • Tumor segmentation based on pO(2) images derived from MR analysis.
  • Inverse treatment planning incorporating dose redistribution for hypoxic compartments.
  • Comparison of uniform and non-uniform IMRT plans for tumor control probability (TCP) and plan quality.

Main Results:

  • DCEMRI successfully identified hypoxic regions, with 28% of the tumor showing pO(2) < 5 mm Hg.
  • Non-uniform dose prescription based on hypoxia imaging resulted in a fourfold higher optimal TCP.
  • Non-uniform IMRT plans achieved a threefold higher TCP compared to uniform plans.
  • Plan quality and TCP were sensitive to IMRT parameters and image errors.

Conclusions:

  • Biologically adapted radiotherapy integrating hypoxia imaging, inverse planning, and IMRT can significantly enhance tumor control.
  • Dose redistribution to target hypoxic subvolumes shows substantial promise for improving radiotherapy outcomes.
  • Further research is warranted to optimize IMRT parameters and mitigate image uncertainties for clinical translation.