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Related Experiment Videos

Life amidst the contrivances.

Noel R Rose1

  • 1Department of Pathology, Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. nrrose@jhsph.edu

Nature Immunology
|September 21, 2006
PubMed
Summary
This summary is machine-generated.

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The concept that the body cannot attack itself was disproven 50 years ago. Research demonstrated that autoimmune thyroiditis can be induced in animals, establishing autoimmunity as a cause of disease.

Area of Science:

  • Immunology
  • Endocrinology
  • Pathology

Background:

  • The prevailing scientific belief, termed 'horror autotoxicus', posited that the body possessed an inherent mechanism preventing self-attack.
  • This dogma dominated medical and biological thought for decades, influencing research directions and clinical understanding of diseases.

Observation:

  • A seminal paper published 50 years ago presented experimental evidence contradicting the 'horror autotoxicus' concept.
  • The study demonstrated the successful induction of autoimmune thyroiditis in animal models.

Findings:

  • The induction of experimental autoimmune thyroiditis provided concrete proof that the immune system can indeed target self-tissues.
  • This finding directly challenged the long-held notion of inherent self-tolerance.

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Implications:

  • The establishment of autoimmunity as a pathological mechanism revolutionized the understanding of numerous diseases.
  • This paradigm shift paved the way for extensive research into the causes and potential treatments for autoimmune disorders.
  • Noel Rose's account highlights the historical significance of this discovery in immunology.