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Related Concept Videos

The Micturition Reflex01:26

The Micturition Reflex

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...

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Related Experiment Video

Updated: Jul 19, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Interventions for detrusor overactivity: the case for multimodal therapy.

Roger Dmochowski

    Reviews in Urology
    |September 21, 2006
    PubMed
    Summary

    Multimodal therapy, combining behavioral, physiotherapeutic, neuromodulatory, and surgical options, offers optimal symptom control for overactive bladder (OAB). This approach provides additive benefits, even for patients refractory to standard treatments.

    Area of Science:

    • Urology
    • Pelvic Health
    • Therapeutic Strategies

    Background:

    • Overactive bladder (OAB) management has advanced with new therapeutic alternatives.
    • Current approaches often focus on stand-alone interventions, which may not suit all patient populations.
    • Unique patient groups may require tailored therapeutic combinations for optimal outcomes.

    Purpose of the Study:

    • To review the evidence supporting multimodal therapy for overactive bladder (OAB).
    • To highlight the benefits of combining behavioral, physiotherapeutic, neuromodulatory, and surgical approaches.
    • To emphasize the efficacy of multimodal therapy in refractory OAB cases.

    Main Methods:

    • Literature review of studies on OAB management.
    • Analysis of evidence for combination therapies.

    Related Experiment Videos

    Last Updated: Jul 19, 2026

    Detrusor Underactivity Model in Rats by Conus Medullaris Transection
    03:26

    Detrusor Underactivity Model in Rats by Conus Medullaris Transection

    Published on: August 28, 2020

  • Examination of outcomes in diverse patient populations.

    • Main Results:

    • Multimodal therapy provides satisfactory symptomatic control for most OAB patients.
    • Combination therapy yields additive benefits, particularly in unique or refractory populations.
    • Evidence supports the efficacy of integrated treatment strategies.

    Conclusions:

    • Multimodal therapy is the optimal approach for managing overactive bladder (OAB) symptoms.
    • Integrating diverse therapeutic components maximizes patient benefit.
    • A comprehensive strategy is essential for challenging OAB cases.