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Controllable Ion Channel Expression through Inducible Transient Transfection
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Controllable Ion Channel Expression through Inducible Transient Transfection

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Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels

Byung-Chang Suh1, Takanari Inoue, Tobias Meyer

  • 1Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA.

Science (New York, N.Y.)
|September 23, 2006
PubMed

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Mechanically-gated Ion Channels

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Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

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Non-gated Ion Channels01:24

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Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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Ligand-gated Ion Channels

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Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
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Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...