Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Updating motor unit number estimation (MUNE).

Mark B Bromberg1

  • 1Department of Neurology, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA. mbromberg@hsc.utah.edu

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|September 26, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Flail Limb Syndrome.

Muscle & nerve·2026
Same author

Genetic contributions to mitochondrial dysfunction in amyotrophic lateral sclerosis etiology.

HGG advances·2026
Same author

Pearls & Oy-sters: Use of Short-Acting B-Agonist in DOK7-Related Congenital Myasthenic Syndrome Treatment.

Neurology·2026
Same author

Predicting Motor Intent from Residual Neck Muscle Activity in Individuals with Neck Weakness from ALS.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

What Is in the Literature.

Journal of clinical neuromuscular disease·2025
Same author

What Is in the Literature.

Journal of clinical neuromuscular disease·2024
Same journal

The middle-latency components of somatosensory evoked potentials help to predict the outcome in of post-anoxic coma: a monocentric study.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

Multimodal intraoperative monitoring of facial nerve function: combined use of blink reflex and corticobulbar motor evoked potentials.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

The contribution of trapezius and sternocleidomastoideus motor evoked potentials in the diagnosis of Amyotrophic lateral sclerosis.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

Modulating corticospinal excitability with transcranial ultrasound stimulation: meta-analytic evidence of online and offline effects.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

Fast oscillations as useful biomarkers of the degree of epileptogenicity in each generalized epilepsy syndrome.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same journal

Neuropsychological, biological, and electrophysiological outcomes of gamma-tACS in MCI-AD: A case series.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
See all related articles

Motor unit number estimation (MUNE) provides a numerical count of muscle-innervating axons. Recent advancements enhance MUNE techniques, improving data acquisition and clinical trial applications for axonal loss disorders.

Area of Science:

  • Electrophysiology
  • Neuromuscular Disorders
  • Biomedical Engineering

Background:

  • Motor unit number estimation (MUNE) is a specialized electrophysiologic method for quantifying innervating axons.
  • Since its inception in 1971, MUNE techniques have evolved to address methodological challenges.
  • A previous review in 2001 highlighted the field's progress.

Purpose of the Study:

  • To provide an updated overview of Motor Unit Number Estimation (MUNE) advancements over the past five years.
  • To discuss new applications and methodological refinements in MUNE.
  • To highlight the growing role of MUNE in clinical research and trials.

Main Methods:

  • Review of recent literature and advancements in MUNE techniques.
  • Inclusion of muscle models for evaluating and comparing MUNE methodologies.

Related Experiment Videos

  • Analysis of modifications aimed at accelerating MUNE data acquisition.

    • Main Results:

    • Development of new MUNE techniques and models for technique evaluation.
    • Investigated specific technical aspects and introduced modifications for faster data collection.
    • Demonstrated increased utilization of MUNE in clinical settings to understand axonal loss pathophysiology.

    Conclusions:

    • MUNE techniques have seen significant development, including improved evaluation models and faster data acquisition.
    • MUNE is increasingly valuable for elucidating axonal loss in various neurological disorders.
    • There is growing evidence supporting MUNE's utility as an endpoint measure in clinical trials for neuromuscular conditions.