Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left bundle-branch block artifact on single photon emission computed tomography with technetium Tc 99m (Tc-99m)

John P Higgins1, Gethin Williams, James S Nagel

  • 1Cardiac Stress Laboratory, Harvard Medical School, VA Boston Healthcare System, Boston, MA, USA. john.higgins@va.gov

American Heart Journal
|September 26, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seronegative Cryoglobulinemic Glomerulonephritis Coexisting With Primary Sjögren Syndrome and HBV Infection: A Diagnostic and Therapeutic Challenge.

Kidney medicine·2026
Same author

Earlier diagnosis of small intestine neuroendocrine tumours (SI-NETs) through transformation of the South Wales NET service.

Journal of neuroendocrinology·2024
Same author

Assessment of Optimal Treatment Strategies and Their Outcomes in T3N1 Rectal Cancers.

Cureus·2024
Same author

Infection-Related GN with Cutaneous Vasculitis.

Clinical journal of the American Society of Nephrology : CJASN·2024
Same author

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research.

Journal of visualized experiments : JoVE·2023
Same author

Erratum to 'Ten Traits of Great Physicians! And Tips to Help You Improve' [The American Journal of Medicine (2023) Volume 136, Issue 4, Pages 355-359].

The American journal of medicine·2023
Same journal

International study of Coronary Microvascular Angina (iCorMicA): a registry-based diagnostic study and nested randomized trial.

American heart journal·2026
Same journal

Stratified Medicine with Eplerenone for Myocardial Infarction or Injury and No obstructive Coronary Arteries: A Registry-Based Basket Trial.

American heart journal·2026
Same journal

Revised Lipid-Lowering Therapy Guidelines in a Nationally Representative Sample.

American heart journal·2026
Same journal

Cardiometabolic Health of Low- and Higher-Income Adults in the United States, 2009-2023.

American heart journal·2026
Same journal

Moving Beyond Technical Capability to Regulatory Integration for Digital Health Technology Devices-Brief Communication from the Cardiovascular Sciences Research Consortium.

American heart journal·2026
Same journal

THE SOCIETY OF CRITICAL CARE CARDIOLOGY - RATIONALE, BLUEPRINT, AND LESSONS LEARNED IN THE CREATION OF A NEW MULTIDISCIPLINARY PROFESSIONAL ORGANIZATION.

American heart journal·2026
See all related articles

Myocardial perfusion scintigraphy can detect coronary artery disease, but left bundle-branch block may cause false positives. True ischemia is identified by specific perfusion defect patterns in myocardial perfusion imaging.

Area of Science:

  • Nuclear Medicine
  • Cardiology
  • Radiology

Background:

  • Myocardial perfusion scintigraphy is a validated noninvasive tool for diagnosing coronary artery disease (CAD).
  • Electrocardiographic changes can be nondiagnostic in some patients, necessitating further evaluation.
  • Left bundle-branch block (LBBB) presents a challenge in interpreting myocardial perfusion imaging due to potential false-positive findings.

Purpose of the Study:

  • To clarify the interpretation of myocardial perfusion scintigraphy in patients with left bundle-branch block.
  • To differentiate true ischemic defects from artifactual defects in the presence of LBBB.

Main Methods:

  • Utilized technetium Tc 99m agents for myocardial perfusion scintigraphy.
  • Analyzed perfusion defects in the septal and anteroseptal walls, common sites for false positives in LBBB.

Related Experiment Videos

  • Investigated mechanisms including impaired microvessel flow and partial-volume effects.

    • Main Results:

    • False-positive perfusion defects in LBBB can be reversible or irreversible, often in the left anterior descending coronary artery territory.
    • Mechanisms include reduced microvascular flow and partial-volume effects in a thin septum.
    • True ischemic findings are characterized by reversible defects at end diastole, apical defects, and matching systolic dysfunction.

    Conclusions:

    • Specific imaging findings can help differentiate true ischemia from false positives in myocardial perfusion scintigraphy with LBBB.
    • Accurate interpretation is crucial for appropriate patient management and avoiding unnecessary interventions.