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B-cell memory: are subsets necessary?

David Tarlinton¹

¹David Tarlinton is at The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia. tarlinton@wehi.edu.au

Nature Reviews. Immunology

|September 26, 2006

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Germinal centers generate memory B cells and plasma cells throughout immune responses. Randomly selected B cells emigrate, with those possessing favorable germinal center histories persisting as memory B cells.

Area of Science:

Immunology
Cell Biology

Background:

B-cell memory relies on memory B cells and long-lived plasma cells.
Both cell types originate from germinal centers, but the specific triggers for memory cell formation are unclear.

Purpose of the Study:

To investigate the signals and circumstances that drive germinal center B cells into memory compartments.
To propose a model for the continuous production and selection of memory B cells and plasma cells within germinal centers.

Main Methods:

This study is primarily theoretical, proposing a model based on existing immunological principles.
It synthesizes current understanding of germinal center dynamics and B-cell differentiation.

Main Results:

Germinal centers continuously produce memory B cells and plasma cells during an immune response.

Related Experiment Videos

Memory B cells are proposed to arise from randomly emigrating B cells from the germinal center pool.

Survival as memory B cells is dependent on the B cell's germinal center history, favoring high-affinity variants.

Conclusions:

Germinal centers are dynamic sites for ongoing memory B cell and plasma cell generation.
Random emigration and selection based on germinal center history are key mechanisms for establishing B-cell memory.