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Updated: Jul 19, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
[The mathematical model of the blood circulation and external respiration functional state during high-pressure
Abstract:
Based on the minimal energy uptake, the proposed mathematical model of blood circulation and external respiration functioning during high-pressure oxygenation or hyperoxia allows solution of the optimization task with restrictions dictated by adequate functioning of the two systems. Optimal levels of oxygen and carbon dioxide pressure in arterial and venous blood, minute blood volume and alveolar ventilation as a function of O2 partial pressure in inspired gas mixture were determined. Calculations are compared with experimentally derived values.
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