Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Optimal structure of the microcirculatory bed

M A Khanin¹, I B Bukharov

¹Department of Microelectronics, Moscow State University of Aircraft Technology, Russia.

Journal of Theoretical Biology

|August 7, 1994

Summary

This study models the microcirculatory system using minimum power principles to optimize blood flow and oxygen transport. Results determine optimal capillary structures and arterial blood volume, validated against human data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Apoptosis induced by granzyme B].

Bioorganicheskaia khimiia·2008

Same author

[The mathematical model of the blood circulation and external respiration functional state during high-pressure oxygenation or hyperoxia].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2006

Same author

[Effects of the oxygen partial pressure in inspired gaseous mixture on the functional state of the circulatory, respiratory and erythropoietic systems: a mathematical model].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2003

Same author

[A mathematical model of the functional state of the hemopoietic and erythropoietic system].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2003

Same author

Blood coagulation dynamics under the conditions of Hageman factor deficiency: a mathematical model.

Doklady. Biochemistry and biophysics·2002

Same author

Effect of factor VIII deficiency on generation of thrombin: a biomechanical approach.

Doklady. Biochemistry and biophysics·2002

Area of Science:

Physiology
Biophysics
Mathematical Biology

Background:

The microcirculatory system's structure is crucial for efficient oxygen delivery.
Understanding the energetic costs of blood circulation is vital for physiological modeling.

Purpose of the Study:

To develop a mathematical model of microcirculatory system organization based on minimum power expenditure.
To determine the optimal structural parameters of the microcirculation in key organs.

Main Methods:

Application of the principle of minimum power to create an optimization model.
Analysis of power expenditure in the heart, bone marrow, and blood transport.
Consideration of microcirculatory bed structures in the heart, lungs, and skeletal muscles.

Main Results:

The model determines the optimal number of capillaries per terminal arteriole based on oxygen transport.
Arterial blood volume is modeled as a function of body weight.
Theoretical predictions are validated through comparison with experimental data from humans.

Conclusions:

The minimum power principle provides a framework for understanding microcirculatory system design.
The model successfully predicts key structural features and blood volume relationships in the human microcirculation.

Related Experiment Videos