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Deterministic hydrodynamics: taking blood apart.

John A Davis1, David W Inglis, Keith J Morton

  • 1Princeton Institute for the Science and Technology of Materials, Princeton University, Princeton, NJ 08544, USA.

Proceedings of the National Academy of Sciences of the United States of America
|September 27, 2006
PubMed
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This study introduces a continuous-flow deterministic array for blood component separation. The technology isolates undiluted blood plasma and removes white blood cells, red blood cells, and platelets efficiently.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Hematology

Background:

  • Accurate separation of blood components is crucial for diagnostics and research.
  • Existing methods for blood plasma isolation can lead to dilution or cellular contamination.
  • Hydrodynamic size-based separation offers a novel approach independent of component mass.

Purpose of the Study:

  • To demonstrate the efficacy of a continuous-flow deterministic array for blood component fractionation.
  • To achieve isolation of undiluted blood plasma with minimal cellular contamination.
  • To validate the separation of white blood cells, red blood cells, and platelets based on hydrodynamic size.

Main Methods:

  • Development and application of a continuous-flow deterministic array technology.

Related Experiment Videos

  • Separation of blood components at flow velocities of 1,000 microm/sec and volume rates up to 1 microl/min.
  • Utilizing focused injection and a second array design for plasma isolation and cell removal.
  • Verification of cell removal using flow cytometry.

    • Main Results:

    • Complete removal of lymphocytes and monocytes from the main blood cell stream was confirmed by flow cytometry.
    • Successful separation of blood plasma from blood cells (white blood cells, red blood cells, platelets).
    • Achieved plasma isolation with virtually no dilution and no cellular contamination.

    Conclusions:

    • Continuous-flow deterministic arrays effectively fractionate whole blood components based on hydrodynamic size.
    • The developed technology enables the isolation of pure, undiluted blood plasma.
    • This method presents a significant advancement for blood processing in clinical and research settings.