Related Experiment Video
Updated: Jul 19, 2026

08:25
Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice
Published on: July 16, 2014
[Direct drug delivery to the brain].
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
|September 28, 2006
Summary
This review explores advanced methods for delivering biological agents to the brain, focusing on micellar and liposomal carriers. These approaches utilize immunochemical vectors to target the blood-brain barrier (BBB) for enhanced therapeutic delivery.
Area of Science:
- Neuroscience
- Biotechnology
- Pharmacology
Context:
- The blood-brain barrier (BBB) presents a significant obstacle to delivering therapeutic agents to the central nervous system.
- Current drug delivery methods have limited efficacy due to the restrictive nature of the BBB.
Purpose:
- To review current and emerging strategies for directed biological agent delivery across the BBB.
- To highlight the potential of micellar and liposomal systems for brain-targeted transport.
Summary:
- Discusses micellar and liposomal drug delivery systems designed to overcome the BBB.
- Focuses on the use of immunochemical vectors, including antibodies, to target specific antigens on the BBB or within brain tissue.
- Explores the application of native or hydrophobized antibodies for enhanced targeting and transport.
Impact:
- Potential for improved therapeutic outcomes in neurological disorders.
- Advances in targeted drug delivery systems for brain diseases.
- Facilitates the development of novel treatments for brain conditions by enabling efficient agent transport.
Related Concept Videos
Drug Delivery: Parenteral Route
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Overview
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Drug Delivery: Miscellaneous Routes
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Drug Delivery: Enteral Route
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Drugs in...
Additional Routes of Drug Administration
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
The Blood-brain Barrier
Overview

