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Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins

Christopher J Hupfeld1, Jerrold M Olefsky

  • 1Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, California 92093, USA. chupfeld@ucsd.edu

Annual Review of Physiology
|September 28, 2006
PubMed

Insights

Receptor tyrosine kinases (RTKs) and seven-transmembrane receptors (7TMRs) can activate similar signaling pathways. This review explores the cross talk between RTKs and 7TMRs, highlighting the roles of beta-arrestins and G proteins.

Area of Science:

  • Cellular signaling pathways
  • Molecular biology
  • Biochemistry

Background:

  • Receptor tyrosine kinases (RTKs) are cell surface receptors with intracellular tyrosine kinase activity.
  • RTKs share signaling molecules and activate similar cascades with seven-transmembrane receptors (7TMRs).

Purpose of the Study:

  • To review the signaling cross talk between RTKs and 7TMRs.
  • To focus on the specific roles of beta-arrestins and G proteins in this cross talk.

Main Methods:

  • Literature review of RTK and 7TMR signaling pathways.
  • Analysis of molecular mechanisms underlying receptor cross talk.

Main Results:

  • RTKs and 7TMRs engage in significant cross talk, influencing cellular responses.
  • Beta-arrestins and G proteins are key mediators in the communication between these receptor families.

Conclusions:

  • Understanding RTK and 7TMR cross talk is crucial for deciphering complex cellular signaling.
  • Beta-arrestins and G proteins play pivotal roles in integrating signals from both receptor types.

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