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[The G/C polymorphism of RAD51 gene in breast cancer]
Hanna Romanowicz-Makowska1, Beata Smolarz, Andrzej Kulig
1Instytut Centrum Zdrowia Matki Polki w Lodzi, Pracownia Biologii Molekularnej, Zakład Patomorfologii Klinicznej.
Unlabelled:
The development of breast cancer is associated with an accumulation of specific genetic alterations. The aim. In this study the distribution of G/G, G/C and C/C genotype and frequencies of the G and C allele of RAD51 G/C polymorphism in women with breast cancer was examined.
Material And Methods:
85 breast cancer samples were included in this study. They were categorised according to Scarf-Bloom-Richardson criteria in women with breast cancer. Blood samples age matched healthy individuals (n = 91) served as control.
Results:
The distribution of the genotypes of the G/C polymorphism RAD51 in both control and patients did not differ significantly (p>0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences in the genotype distributions and allele frequencies between node-positive and node-negative patients.
Conclusion:
Our study implies that it is possible that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer but further researches, conducted on larger population, are needed to clarify this point.
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