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Challenged by complexity: my twentieth century in immunology
1Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia. peter.doherty@stjude.org
Annual Review of Immunology
|September 30, 2006
Summary
Discoveries in virus-induced infectious processes revolutionized immunology. The identification of MHC I-restricted CD8(+) T cell recognition significantly advanced our understanding of cell-mediated immunity.
Area of Science:
- Immunology
- Virology
- Medical Research
Background:
- Research focused on complex experimental systems, particularly virus-induced infectious processes.
- Early career involved veterinary science and neuropathology, followed by a PhD.
- Transitioned to basic medical science, focusing on cell-mediated immunity and mouse models.
Discussion:
- Co-discovery of MHC I-restricted CD8(+) T cell recognition in 1973.
- Development of the "single T cell receptor/altered self" hypothesis.
- Nobel Prize in Physiology or Medicine in 1996 for these contributions.
Key Insights:
- MHC I molecules restrict T cell recognition.
- CD8(+) T cells play a crucial role in adaptive immunity.
- This discovery fundamentally changed the understanding of immune surveillance and response.
Outlook:
- Continued focus on communicating the societal value of scientific advancements.
- The foundational nature of this work continues to influence current immunological research.
- The historical account is limited to the 20th century.
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