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Related Experiment Videos

Thyroid function in pulmonary tuberculosis.

Khan Mohammad Sajid1, Riffat Parveen, Durr-e- Sabih

  • 1Laboratory Section, Multan Institute of Radiotherapy and Nuclear Medicine (MINAR), Multan. kmsajid@yahoo.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|September 30, 2006
PubMed
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Pulmonary tuberculosis (PTB) significantly lowers thyroid hormones triiodothyronine (T3) and thyroxine (T4), but not thyroid stimulating hormone (TSH). Treatment with chemotherapy improved these hormone levels in patients with PTB.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Pulmonology

Background:

  • Pulmonary tuberculosis (PTB) is a significant global health concern.
  • Thyroid hormone economy can be affected by severe illness.
  • Understanding these effects is crucial for comprehensive patient management.

Purpose of the Study:

  • To investigate the impact of pulmonary tuberculosis on thyroid hormone levels.
  • To evaluate the thyroid hormone economy in PTB patients.
  • To assess the effect of chemotherapy on thyroid hormone levels in PTB.

Main Methods:

  • A cohort comparative study was conducted with 266 PTB patients.
  • Radioimmunoassays and immunoradiometric assays were used to measure T3, T4, and TSH levels.
  • Student's t-test was employed for statistical analysis comparing PTB patients to 713 healthy volunteers.

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Main Results:

  • Mean T3 and T4 levels were significantly decreased in PTB patients (p < 0.001).
  • 50% of PTB patients had lower than normal T3, and 11.6% had lower than normal T4.
  • TSH levels remained unaffected in PTB patients, and T3/T4 levels improved post-chemotherapy.

Conclusions:

  • PTB induces euthyroid sick syndrome, characterized by decreased T3 and T4 with unaffected TSH.
  • Thyroxine (T4) levels were less affected than triiodothyronine (T3) levels.
  • Chemotherapy effectively reverses the thyroid hormone abnormalities associated with PTB.