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Published on: February 10, 2023

Venous thrombosis and thromboembolism in children with osteomyelitis

Shelley E Crary1, George R Buchanan, Casey E Drake

  • 1University of Texas Southwestern Medical Center at Dallas, Division of Pediatric Hematology-Oncology, Dallas, Texas 75390, USA. shelley.crary@utsouthwestern.edu

The Journal of Pediatrics
|October 3, 2006
PubMed

Insights

Deep vein thrombosis (DVT) complicates childhood osteomyelitis in 29% of high-risk cases. Children with DVT faced longer hospital stays and increased risk of disseminated infection.

Area of Science:

  • Pediatric infectious diseases
  • Pediatric hematology
  • Pediatric orthopedics

Background:

  • Osteomyelitis is a serious bone infection in children.
  • Thromboembolic events are a potential complication of severe infections.

Purpose of the Study:

  • To investigate the occurrence and characteristics of deep vein thrombosis (DVT) in children diagnosed with osteomyelitis.
  • To identify risk factors and clinical outcomes associated with DVT in pediatric osteomyelitis.

Main Methods:

  • Retrospective review of medical records for pediatric patients with osteomyelitis.
  • Analysis focused on patients with osteomyelitis in high-risk locations (proximal extremities, pelvis, vertebrae).
  • Diagnostic confirmation of DVT through imaging studies.

Main Results:

  • Twenty-nine percent (10 of 35) of high-risk pediatric osteomyelitis patients developed DVT.
  • DVT occurred adjacent to the infection site or related to central venous catheters.
  • Patients with DVT had significantly longer hospitalizations and a higher incidence of disseminated infection (lung, brain, heart).

Conclusions:

  • Deep vein thrombosis is a significant complication in childhood osteomyelitis.
  • Children with osteomyelitis and DVT are at increased risk for severe, disseminated infections.
  • Early recognition and management of DVT may be crucial in pediatric osteomyelitis cases.
Abstract

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