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Related Experiment Videos

Solifenacin.

Karl J Kreder1

  • 1Department of Urology, University of Iowa, 200 Hawkins Drive, 3 RCP, Iowa City, IA 52242-1089, USA. karl-kreder@uiowa.edu

The Urologic Clinics of North America
|October 3, 2006
PubMed
Summary
This summary is machine-generated.

Solifenacin succinate offers an effective and well-tolerated treatment for overactive bladder. This antimuscarinic agent increases bladder capacity and reduces urinary urgency, frequency, and incontinence with minimal side effects.

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Area of Science:

  • Urology
  • Pharmacology

Background:

  • Pharmacologic therapy is the primary treatment for overactive bladder (OAB).
  • New antimuscarinic agents have emerged for OAB management.

Purpose of the Study:

  • To evaluate solifenacin succinate as a novel, once-daily treatment for overactive bladder.
  • To assess the efficacy and tolerability of solifenacin succinate in OAB patients.

Main Methods:

  • Clinical trials were conducted to assess solifenacin succinate's effects.
  • Pharmacokinetic studies investigated drug distribution and selectivity.

Main Results:

  • Solifenacin succinate effectively increases functional bladder capacity.
  • The agent significantly decreases urinary urgency, frequency, and incontinence.

Related Experiment Videos

  • Pharmacokinetic studies indicated bladder selectivity, correlating with low incidence of dry mouth and constipation.

    • Conclusions:

    • Solifenacin succinate is an effective and well-tolerated treatment option for overactive bladder.
    • Its bladder selectivity contributes to a favorable side effect profile, particularly reduced dry mouth and constipation.