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Related Experiment Videos

Ethanol and opiate decrease the axonal transport of substance-P like immunoreactive material in rat vagus-nerves.

P A De Witte1, M Hamon, A Mauborgne

  • 1Centre Albert Michotte, Université de Louvain, Belgique.

Neuropeptides
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

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Chronic alcohol exposure in rats reduces substance P transport in nerves. Opiate drugs mimic this effect, suggesting opioid involvement in alcoholism and addiction.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Chronic alcohol consumption is linked to altered neural pathways.
  • Previous studies noted enhanced retrograde axonal transport of opiates in alcohol-treated rats.

Purpose of the Study:

  • To investigate the effect of chronic alcohol treatment on anterograde axonal transport of substance P.
  • To explore the role of opioid systems in alcohol-induced changes in substance P transport.

Main Methods:

  • Rats were treated with alcohol for up to 24 days.
  • Substance P like immunoreactive material (SPLM) accumulation in ligated vagus nerves was measured.
  • Effects of acute opiate agonist (lofentanil) and antagonist (naloxone) administration were assessed.
  • Alcohol preference was evaluated in choice tests with opiate administration during alcoholization.

Related Experiment Videos

Main Results:

  • Chronic alcohol treatment decreased SPLM accumulation in ligated vagus nerves.
  • Acute administration of an mu opiate agonist (lofentanil) replicated this decrease in SPLM transport.
  • Naloxone prevented the lofentanil-induced reduction of SPLM transport.
  • Administration of naloxone or bezitramide during alcoholization reduced alcohol preference.

Conclusions:

  • Chronic alcoholism alters anterograde axonal transport of substance P.
  • Opioid systems, involving substance P, likely play a role in chronic alcoholism.
  • A common mechanism may underlie drug addiction and chronic alcoholism.