Related Experiment Video

Updated: Jul 19, 2026

Generation of a Bovine Primary Enteroid-Derived Two-Dimensional Monolayer Culture System for Applications in Translational Biomedical Research
07:56

Generation of a Bovine Primary Enteroid-Derived Two-Dimensional Monolayer Culture System for Applications in Translational Biomedical Research

Published on: April 5, 2024

Disease emergence in multi-host epidemic models

Robert K McCormack1, Linda J S Allen

  • 1Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX 79409-1042, USA. rmccormack16@hotmail.com

Mathematical Medicine and Biology : a Journal of the IMA
|October 3, 2006
PubMed

Insights

The emergence of infectious diseases increases with the number of hosts a pathogen can infect. This study develops multi-host epidemic models to understand disease spread and emergence conditions.

Area of Science:

  • Epidemiology
  • Mathematical Biology
  • Infectious Disease Dynamics

Background:

  • Pathogens often infect multiple hosts, creating diverse transmission routes.
  • Understanding multi-host pathogen dynamics is crucial for predicting and controlling disease emergence.

Purpose of the Study:

  • To formulate and analyze multi-host epidemic models (SIS and SIR).
  • To determine conditions for disease emergence in multi-host systems.
  • To investigate the impact of the number of hosts on disease spread.

Main Methods:

  • Formulation of Susceptible-Infected-Susceptible (SIS) and Susceptible-Infected-Recovered (SIR) epidemic models for 'n' hosts.
  • Computation of the basic reproduction number (R0).
  • Analysis of the global stability of endemic equilibria for the two-host SIS model.

Main Results:

  • The basic reproduction number increases with the number of hosts ('n').
  • The likelihood of disease emergence is positively correlated with the number of infected hosts.
  • Conditions for the global stability of endemic states were derived for the two-host model.

Conclusions:

  • Increasing the number of hosts amplifies the potential for infectious disease emergence.
  • The developed models provide insights into zoonotic diseases like hantavirus.
  • Mathematical modeling is essential for understanding complex epidemiological patterns in multi-host systems.

More Related Videos

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

Related Concept Videos

Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results from...
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Causality in Epidemiology01:21

Causality in Epidemiology

Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...