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Peripheral vascular surgery: does anesthetic management affect outcome?

J A Colombo1, K J Tuman

  • 1Department of Anesthesiology, Rush Medical College at Rush-Presbyterian-St Luke's Medical Center, Chicago, Illinois 60612, USA.

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General Anesthesia: Overview

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The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
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