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Novel ways of preventing antibiotic-resistant infections: what might the future hold?
Mary-Claire Roghmann1, Linda McGrail
1Epidemiology Section, Medical Care Clinical Center, VA Maryland Health Care System, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. mroghman@epi.umaryland.edu
Abstract:
Most antibiotic-resistant bacteria are opportunistic pathogens; they colonize the skin and mucosal surfaces and only cause infection when the opportunity arises. Thus, the processes that lead to an infection attributable to antibiotic-resistant bacteria can be broadly divided into those processes that lead to acquisition of antibiotic-resistant bacteria and those that lead to the development of an infection with that organism. We review the processes that lead to the development of infections attributable to antibiotic-resistant bacteria. We then discuss options that may become available to interrupt these processes and, thus, may reduce the rate of infections attributable to antibiotic-resistant bacteria in the future.
Insights
Antibiotic-resistant bacteria often cause infections opportunistically. This review examines how these infections develop and potential future strategies to reduce their occurrence.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Opportunistic pathogens, including antibiotic-resistant bacteria, colonize host surfaces.
- Infections arise when these bacteria exploit favorable conditions.
- Understanding colonization and infection development is crucial for control.
Purpose of the Study:
- To review the processes leading to infections caused by antibiotic-resistant bacteria.
- To discuss potential future interventions for reducing these infections.
Main Methods:
- Literature review of existing research on antibiotic-resistant bacteria and infection development.
- Analysis of factors contributing to bacterial acquisition and subsequent infection.
Main Results:
- Infections are broadly categorized by acquisition of resistant bacteria and subsequent infection development.
- The review synthesizes current knowledge on these two key processes.
Conclusions:
- Interventions targeting bacterial acquisition and infection development are needed.
- Future strategies may focus on interrupting these processes to lower infection rates.
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