Radical-scavenging activities of new megastigmane glucosides from Macaranga tanarius (L.) MULL.-ARG
Katsuyoshi Matsunami1, Ichiko Takamori, Takakazu Shinzato
1Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Chemical & Pharmaceutical Bulletin
|October 4, 2006
Abstract:
Four new megastigmane glucosides, named macarangiosides A-D (2-5), together with mallophenol B, lauroside E, methyl brevifolin carboxylate, and hyperin and isoquercitrin as a mixture were isolated from the leaves of Macaranga tanarius (L.) MULL.-ARG. (Euphorbiaceae). Their structures were elucidated by spectroscopic and chemical analyses. Macarangioside A-C (2-4) and mallophenol B were galloylated on glucose moiety and possessed the potent 2,2-diphenyl-picrylhydrazyl (DPPH) radical-scavenging activity.