Marine halogenated natural products of environmental relevance

A wide range and steadily increasing number of halogenated natural products (HNPs) is detected in marine organisms that are not the natural source of these compounds but which have accumulated these HNPs in a similar way as known to occur with anthropogenic halogenated pollutants such as PCBs and DDT. The HNPs have aromatic, aliphatic, and heterocyclic spines and are brominated, chlorinated, or mixed halogenated (Cl and Br). The exact isomer structures of HNPs are often closely related to the anthropogenic POPs, and for some compounds both natural and anthropogenic sources are likely to exist. Some of the HNPs are nonpolar, persistent, and can thus be found even in marine mammals and birds of prey. The most important HNPs detected in top predators are halogenated 1,1'-dimethyl-2,2'-bipyrroles (HDBPs), the heptachloro-1'-methyl-1,2'-bipyrrole Q1, the tetrabromophenoxyanisole isomers 6-MeO-BDE 47 and 2'-MeO-BDE 68, and related compounds. Each of these compounds has been detected in higher trophic biota with concentrations exceeding 1 mg/kg.