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Multiple system atrophy and autonomic failure.

C J Mathias1

  • 1Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St. Mary's Hospital, UK. c.mathias@imperial.ac.uk

Journal of Neural Transmission. Supplementum
|October 5, 2006
PubMed
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Multiple system atrophy (MSA) is a rare adult neurodegenerative disease. This review covers its clinical features, autonomic dysfunction, and management strategies.

Area of Science:

  • Neurology
  • Neurodegenerative Diseases

Background:

  • Multiple system atrophy (MSA) is a sporadic adult-onset neurodegenerative disorder.
  • Characterized by autonomic failure impacting cardiovascular, urinary, sexual, gastrointestinal, and sudomotor functions.
  • Accompanied by motor deficits, presenting as parkinsonian and/or cerebellar features.

Purpose of the Study:

  • To provide a comprehensive overview of Multiple System Atrophy (MSA).
  • To detail the clinical manifestations, diagnostic investigations, and management approaches for MSA.
  • To emphasize the critical role and impact of autonomic failure in MSA.

Main Methods:

  • Literature review of clinical features, investigations, and management of MSA.
  • Focus on studies detailing autonomic dysfunction in MSA patients.

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  • Synthesis of current knowledge on parkinsonian and cerebellar symptoms.

    • Main Results:

    • MSA presents with diverse autonomic dysfunctions affecting multiple organ systems.
    • Motor symptoms include parkinsonism and/or cerebellar signs.
    • Management requires a multi-faceted approach addressing both autonomic and motor deficits.

    Conclusions:

    • Multiple system atrophy is a complex neurodegenerative disorder with significant autonomic involvement.
    • Early recognition and management of autonomic failure are crucial for patient care.
    • Further research is needed to improve understanding and treatment of MSA.