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Squamous cell carcinoma of the prostate
N Wernert1, R Goebbels, H Bonkhoff
1Institute of Pathology, University of the Saarland, Federal Republic of Germany.
Histopathology
|October 1, 1990
Summary
This study classifies squamous cell carcinoma of the prostate into four types based on histology and behavior. Accurate diagnosis is crucial, considering various origins for prostate squamous cell carcinoma.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Squamous cell carcinoma (SCC) of the prostate is rare and can arise from different origins.
- Histological classification is essential for understanding its behavior and prognosis.
Purpose of the Study:
- To categorize prostate SCC based on histological features and clinical outcomes.
- To investigate the potential origins and immunohistochemical characteristics of prostate SCC.
Main Methods:
- Histological examination of eleven prostate SCC cases.
- Classification into four groups based on morphology and clinical history.
- Immunohistochemical analysis of squamous components for keratin types, CEA, and PNA.
Main Results:
- Four distinct groups identified: pure SCC, adenocarcinoma with squamous change, urothelial carcinoma with squamous metaplasia, and bladder SCC invading prostate.
- Squamous components demonstrated invasion into prostatic stroma and ducts.
- Immunohistochemistry revealed specific keratin types, carcinoembryonic antigen (CEA), and peanut agglutinin (PNA) binding sites in squamous areas.
- Patient survival ranged from 1 to 17 months.
Conclusions:
- Prostate SCC exhibits diverse histological patterns and origins.
- Distinguishing between primary prostate SCC and secondary involvement from the bladder or urothelium is critical.
- Immunohistochemistry aids in characterizing the squamous components.