Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peptide Bonds

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Modeling hERG Channel Liability: From Structural Insight to Highly Accurate Qualitative and Quantitative Models.

Journal of chemical information and modeling·2026

Same author

Assessment of ADC Higher Order Structure Through 2D NMR Analysis.

Molecules (Basel, Switzerland)·2025

Same author

Key themes and approaches in palliative and end-of-life care education for the general public: a systematic review.

BMC palliative care·2025

Same author

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity.

Nature·2025

Same author

Discovery of novel and selective GPR17 antagonists as pharmacological tools for developing new therapeutic strategies in diabetes and obesity.

European journal of medicinal chemistry·2025

Same author

Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning.

Biology·2025

Same journal

Recent Advancements in the Development of Heterocyclic Scaffolds as Potential Anti-cancer Agents Targeting EGFR and VEGFR-2.

Mini reviews in medicinal chemistry·2026

Same journal

Exploring the Anticancer Potential of Synthetic β-Carboline Derivatives: A Comprehensive Systematic Review.

Mini reviews in medicinal chemistry·2026

Same journal

KIF20A in Human Malignancies: Oncogenic Mechanisms and Therapeutic Targeting Strategies.

Mini reviews in medicinal chemistry·2026

Same journal

Phytocompound-loaded Biomaterial-based Scaffolds: Emerging Strategies for Wound Healing Applications.

Mini reviews in medicinal chemistry·2026

Same journal

Bioprospecting of Natural Products as Sources of New Multitarget Therapies.

Mini reviews in medicinal chemistry·2026

Same journal

Boosting the Functional Potential of Pectin: Recent Progress in Antimicrobial Applications through Structural Modifications (2020-2025).

Mini reviews in medicinal chemistry·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 4, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

Utilizing peptide structures as keys for unlocking challenging targets.

David Fry¹, Hongmao Sun

¹Department of Discovery Chemistry, Hoffmann-La Roche, Nutley, NJ, USA.

Mini Reviews in Medicinal Chemistry

|October 5, 2006

Summary

This summary is machine-generated.

Structural insights from peptide ligands aid drug discovery when protein structures are unavailable. This approach helps identify drug targets and design improved small molecule drugs.

More Related Videos

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Peptide-based Identification of Functional Motifs and their Binding Partners

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Related Experiment Videos

Last Updated: Jan 4, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Peptide-based Identification of Functional Motifs and their Binding Partners

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Area of Science:

Medicinal Chemistry
Structural Biology
Pharmacology

Background:

Three-dimensional protein structures are crucial for drug design.
G-protein coupled receptors (GPCRs) often lack attainable structures.
Structural information from active ligands is vital for understanding active sites.

Purpose of the Study:

To review the utility of peptide ligands in drug discovery.
To demonstrate how peptide structures elucidate target active sites.
To guide the design of small molecule drugs.

Main Methods:

Utilizing structural information from peptide ligands.
Employing nuclear magnetic resonance (NMR) for structural investigation.
Developing pharmacophore models from peptide structures.

Main Results:

Peptide ligands provide valuable geometrical and chemical insights into protein active sites.
Quantitative structure-activity relationships (QSAR) are efficiently generated using peptides.
Accurate pharmacophore models are derived from peptide structural data.

Conclusions:

Structural studies of peptide ligands enhance understanding of target active sites.
Peptide-based structural information aids in virtual screening and drug design.
This approach facilitates the development of peptidomimetics and non-peptidic leads.