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Matrix metalloproteinase-2 and -9 expression in sinonasal inverted papilloma
J F Papon1, E Lechapt-Zalcman, M Abina
1Service d'ORL et de Chirurgie Cervico-Faciale, Hopital Henri Mondor, Assistance Publique-Hopitaux de Paris, Créteil, France. jean-francois.papon@hmn.aphp.fr
Rhinology
|October 6, 2006
Summary
Matrix metalloproteinase-9 (MMP-9) expressing inflammatory cells may contribute to inverted papilloma (IP) development. This study investigated MMP-2 and MMP-9 expression in sinonasal tract lesions.
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Inverted papilloma (IP) is a sinonasal tract lesion known for recurrence and association with cancer.
- The role of matrix metalloproteinases (MMPs), specifically MMP-2 and MMP-9, in IP development is not fully understood.
Purpose of the Study:
- To investigate the expression and potential role of MMP-2 and MMP-9 in inverted papilloma.
- To compare MMP expression in IP with nasal polyps (NP) and control nasal mucosa (CM).
Main Methods:
- Immunohistochemistry was used to analyze MMP-2 and MMP-9 expression in 15 IP specimens.
- IP samples were compared to 12 NP and 6 CM samples.
- MMP expression was analyzed in tumoral and non-tumoral areas within IP.
Main Results:
- Epithelial expression of MMP-2 and MMP-9 in IP did not differ from CM and NP.
- Submucosal MMP-9 expression in inflammatory cells was similar between IP, CM, and NP.
- A significant increase in MMP-9 positive inflammatory cells was found adjacent to hyperplastic epithelium within IP compared to non-hyperplastic areas.
Conclusions:
- MMP-9 expressing inflammatory cells appear to play a role in the pathophysiology of inverted papilloma.
- Further research into the inflammatory mechanisms underlying IP is warranted.