[Participation of endogenous brain histamine on learning and memory]

It is well known that histamines play an important role as a neurotransmitter in the central nervous system and participate in several physiological functions, such as the regulation of body temperature, food intake, circadian rhythm and analgesia. Since the first report by de Almeida and Izquierdo that histamines facilitate memory performance in mice, it has been revealed that the histaminergic nervous system in the brain plays a crucial role in learning and memory functions. First, we demonstrate the effects of histamines and histaminergic drugs on learning and memory using active avoidance and 8-arm radial maze tests. Many reports suggest that acetylcholine and N-methyl-D-aspartate (NMDA) receptors play an important role in learning and memory. In this report, we also describe the interaction between histamine-induced memory facilitation and acetylcholine or NMDA receptors.