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Updated: Jul 19, 2026
07:32
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
beta-Estradiol biodegradable microspheres: effect of formulation parameters on encapsulation efficiency and in vitro
1Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, Safat. abdel@hsc.edu.kw
Die Pharmazie
|October 6, 2006
Summary
This study investigated how organic solvents and surfactants affect beta-estradiol release from PLA/PLGA microspheres. Ethyl acetate and polyvinyl alcohol formulations optimized encapsulation efficiency and reduced initial drug burst.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Biodegradable polymers like PLA/PLGA are crucial for controlled drug delivery systems.
- Beta-estradiol delivery requires careful formulation to manage release kinetics and encapsulation efficiency.
Purpose of the Study:
- To evaluate the impact of organic solvent and surfactant choice on beta-estradiol release from PLA/PLGA microspheres.
- To specifically analyze the influence on initial burst release and overall encapsulation efficiency.
- To identify optimal formulation parameters for controlled beta-estradiol delivery.
Main Methods:
- Microspheres prepared using solvent evaporation technique with various organic solvents (DCM, EtAc, THF, CHCl3, AC) and surfactants (PVA, Tween 80, SLS, BKCI).
- In vitro drug release studies conducted in a 50% methanol/buffer pH 7.4 dissolution medium.
- Encapsulation efficiency assessed, and optimized formulations characterized for particle size, SEM, and zeta potential.
Main Results:
- Ethyl acetate (EtAc) as solvent and polyvinyl alcohol (PVA) as surfactant yielded the highest encapsulation efficiency.
- These EtAc and PVA formulations demonstrated the lowest burst release of beta-estradiol.
- Further characterization confirmed the suitability of these microspheres for controlled release applications.
Conclusions:
- Organic solvent and surfactant selection significantly influences beta-estradiol encapsulation and release from PLA/PLGA microspheres.
- EtAc and PVA represent promising choices for developing effective biodegradable controlled delivery systems for beta-estradiol.
- The findings provide a foundation for optimizing PLA/PLGA microsphere formulations for enhanced drug delivery performance.
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