Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue
John T Tomlinson1, Gyungse Park, Jacob A Misenheimer
1Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, USA.
Organic Letters
|October 6, 2006
Abstract:
[reaction: see text] The prodigiosin alkaloid 1 and the synthetic analogue 2 show photoinduced cytotoxicity against HL-60 cancer cells. Photoirradiation of 1 and 2 causes photofading, photooxidation, and thioadduct formation. These results provide a model for the redox properties of prodigiosins that play a role in their biological activity and provide a new way to functionalize their pyrromethene entity with water-soluble thiol groups.
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