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Galanin stimulates immunoreactive growth hormone-releasing factor secretion from rat hypothalamic slices perifused in
1Department of Medicine, Kobe University School of Medicine, Japan.
Life Sciences
|January 1, 1990
Abstract:
The effect of galanin (GAL) on the release of GH-releasing factor (GRF) and somatostatin (SRIF) was examined in an in vitro perifusion system of rat hypothalamic slices. GAL at doses of 10(-7) and 10(-6)M stimulated the release of immunoreactive GRF while it failed to affect SRIF release. Therefore, in vivo stimulation of GH release by GAL may be explained in part by the GRF-releasing effect of this peptide.