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Fetotoxicity of hexachlorocyclohexane (HCH) in mice: morphological, biochemical and residue evaluations
T S Dikshith1, M K Srivastava, R B Raizada
1Industrial Toxicology Research Centre, Mahatama Gandhi Marg, Lucknow, India.
Veterinary and Human Toxicology
|December 1, 1990
Abstract:
Administration of single po doses of technical hexachlorocyclohexane (HCH) (5, 25, 50, 100 or 200 mg/kg) to mice on day 9 of gestation caused dose-related toxic effects in the fetuses. HCH-treated dams had consistent decreases. The percent resorption and the number of live fetuses/dam indicated that high concentrations of HCH trigger fetotoxic effects. Enzymatic changes in the livers of control and HCH-treated groups showed significant alterations. Accumulation of HCH was in the fatty tissue, brain, liver and blood.