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Updated: Jul 19, 2026

Using Human Intestinal Organoids to Understand the Small Intestine Epithelium at the Single Cell Transcriptional Level
Published on: June 28, 2024
Molecular and cellular biology of the small intestine
C Jobin1, K E Behrns, D A Brenner
1Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC 27599-7080, USA.
Abstract:
The crypt-villus axis is composed of a dynamic cell population in perpetual change from a crypt proliferative and undifferentiated stage to a mature villus stage. The migration of crypt cells is accompanied by cellular differentiation that leads to morphological and functional changes. In addition to this intrinsic gene program, intestinal epithelial cells respond to extrinsic signals by producing various molecules. Using different experimental approaches, recent studies have further characterized intestinal epithelial-cell biology and provided evidence of their polyvalent and important role in gut homeostasis.
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