Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholestatic syndromes.

M Trauner1, J L Boyer

  • 1Karl Franzens University School of Medicine, Graz, Austria.

Current Opinion in Gastroenterology
|October 7, 2006
PubMed
Summary
This summary is machine-generated.

Recent advances in cholestatic liver disease include identifying molecular causes of syndromes, understanding apoptosis in liver injury, and developing new treatments for symptoms like pruritus and fatigue.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary sclerosing cholangitis: time to rethink imaging criteria for early disease detection.

Journal of hepatology·2026
Same author

Conserved Ductular Reaction Mechanisms in Biliary Atresia and Primary Sclerosing Cholangitis Derived From Single-Cell and Spatial Transcriptomics.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Anaemia is independently associated with mortality in patients with hepatocellular carcinoma.

ESMO open·2024
Same author

Clinical characteristics and outcome of patients with combined hepatocellular-cholangiocarcinoma-a European multicenter cohort.

ESMO open·2023
Same author

Cancer and hepatic steatosis.

ESMO open·2021
Same author

Impact of high-volume, intermediate-volume and low-volume bowel preparation on colonoscopy quality and patient satisfaction: An observational study.

United European gastroenterology journal·2019
Same journal

Endoscopic techniques to minimize gastroesophageal reflux during peroral endoscopic myotomy.

Current opinion in gastroenterology·2026
Same journal

Postendoscopy esophageal adenocarcinoma and neoplasia: current status and future directions.

Current opinion in gastroenterology·2026
Same journal

The complement system in inflammatory bowel disease: from early observations to emerging frontiers.

Current opinion in gastroenterology·2026
Same journal

Goblet cell-associated antigen passages in health and disease.

Current opinion in gastroenterology·2026
Same journal

Inflammatory bowel diseases 2026: form, function and therapeutic considerations for the epithelial barrier.

Current opinion in gastroenterology·2026
Same journal

Dietary protein as a regulator of colitis and colorectal cancer.

Current opinion in gastroenterology·2026
See all related articles

Area of Science:

  • Hepatology and Gastroenterology
  • Molecular Biology
  • Pathophysiology

Background:

  • Cholestatic liver diseases represent a significant clinical challenge.
  • Understanding the molecular mechanisms underlying these conditions is crucial for effective management.
  • Key symptoms such as pruritus and fatigue significantly impact patient quality of life.

Purpose of the Study:

  • To review recent advancements in the understanding and treatment of cholestatic liver diseases.
  • To highlight the identification of molecular targets in hepatobiliary transport systems.
  • To discuss new insights into the pathogenesis and management of cholestasis.

Main Methods:

  • Review of recent scientific literature and clinical studies.
  • Analysis of molecular cloning data for hepatobiliary transport systems.

Related Experiment Videos

  • Examination of research on apoptosis as a mechanism of liver injury.

    • Main Results:

    • Identification of the molecular basis for hereditary and acquired cholestatic syndromes.
    • Apoptosis recognized as a key mechanism in cholestatic liver injury and bile duct loss.
    • New therapeutic strategies developed for pruritus and fatigue associated with cholestasis.

    Conclusions:

    • Significant progress has been made in understanding cholestatic liver diseases.
    • Molecular insights are driving the development of targeted therapies.
    • Further research continues to refine the diagnosis and treatment of various cholestatic conditions, including primary biliary cirrhosis, primary sclerosing cholangitis, cholestasis of pregnancy, and drug-induced cholestasis.