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Updated: Jul 19, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Chest pain of esophageal origin
1MCP-Hahnemann University School of Medicine, Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania 19146, USA.
Abstract:
The treatment of patients with unexplained chest pain is difficult and challenging. After a cardiac etiology has been ruled out, a diligent search for an esophageal etiology-gastroesophageal reflux disease, motility abnormalities, or esophageal hypersensitivity-should be undertaken with judicious use of a diagnostic (therapeutic) trial of therapy, ambulatory pH monitoring, or esophageal manometry. The recent literature discusses the use of high-dose omeprazole in diagnosing and treating chest pain associated with gastroesophageal reflux disease, correlates abnormal ambulatory pH monitoring with response to omeprazole, and provides additional insights into the pathogenesis of esophageal chest pain.
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