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Updated: Jul 19, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
[Subjective quality of life of patients with obsessive-compulsive disorder compared to the general population]
Katarina Stengler-Wenzke1, Michael Kroll, Herbert Matschinger
1Klinik und Poliklinik für Psychiatrie, Universität Leipzig, Germany. stenglk@medizin.uni-leipzig.de
Background:
Patients with obsessive-compulsive disorder (OCD) not only suffer from obsessive-compulsive symptoms, but also the disorder is associated with impaired social functioning, which impact their everyday life negatively.
Objective:
Subjective quality of life (QoL) in patients with OCD was examined and compared to the general German population.
Methods:
75 patients with OCD (ICD-10 F42.0-F42.2) were recruited from the outpatient clinic for anxiety disorders at the Department of Psychiatry of the University of Leipzig. Patients showing psychiatric co-morbidity were excluded. By means of the WHOQOL-BREF, QoL was assessed in patients with OCD and in a sample of the general population of Saxony/Germany.
Results:
Compared with the general population, QoL in patients with obsessive-compulsive disorders was lower in all domains of the WHOQOL-BREF.
Conclusion:
OCD has a substantial adverse effect on patients' subjective QoL. Therefore, it will be necessary to include interventions in the treatment of OCD aimed at improving residual deficits in psychosocial functioning and QoL.
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