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Updated: Jul 19, 2026

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
Published on: October 25, 2017
Sequence sensitivity of breathing dynamics in heteropolymer DNA
Tobias Ambjörnsson1, Suman K Banik, Oleg Krichevsky
1NORDITA, Blegdamsvej 17, DK-2100 Copenhagen Ø, Denmark.
Abstract:
We study the fluctuation dynamics of localized denaturation bubbles in heteropolymer DNA with a master equation and complementary stochastic simulation based on novel DNA stability data. A significant dependence of opening probability and waiting time between bubble events on the local DNA sequence is revealed and quantified for a biological sequence of the T7 bacteriophage. Quantitative agreement with data from fluorescence correlation spectroscopy is demonstrated.
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