Related Experiment Video
Updated: Jul 19, 2026
08:16
An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
Published on: July 7, 2017
IFN gamma and CXCR-1 gene polymorphisms in idiopathic bronchiectasis
R J Boyton1, C Reynolds, F N Wahid
1Lung Immunology Group, Infection and Immunity & National Heart and Lung Institute, Sir Alexander Fleming Building, South Kensington Campus, Faculty of Medicine, Imperial College, London SW7 2AZ, UK. r.boyton@imperial.ac.uk
Tissue Antigens
|October 10, 2006
Summary
This study found no link between specific gene variations and idiopathic bronchiectasis, a chronic lung disease. Investigating CXCR-1 and interferon-gamma (IFNgamma) gene polymorphisms did not reveal an association with disease susceptibility in patients.
Area of Science:
- Immunogenetics
- Pulmonology
- Molecular Medicine
Background:
- Idiopathic bronchiectasis involves chronic lung infection, inflammation, and damage, potentially linked to immune system defects.
- Airway inflammation in bronchiectasis features elevated interleukin-8 (IL-8) and neutrophil/T cell infiltration.
- Association with autoimmune diseases like ulcerative colitis suggests immune system involvement.
Purpose of the Study:
- To investigate the association of two candidate gene polymorphisms with idiopathic bronchiectasis susceptibility.
- To examine the CXCR-1 (+2607 G/C) polymorphism's role in IL-8 binding and neutrophil trafficking.
- To assess the interferon-gamma (IFNgamma) (+874 T/A) polymorphism's link to IFNgamma production levels.
Main Methods:
- Case-control study design comparing patients with idiopathic bronchiectasis and healthy controls.
- Genotyping analysis for the CXCR-1 (+2607 G/C) gene polymorphism.
- Genotyping analysis for the interferon-gamma (IFNgamma) (+874 T/A) gene polymorphism.
Main Results:
- The distribution of the CXCR-1 (+2607 G/C) polymorphism was similar between the bronchiectasis group and controls.
- The distribution of the interferon-gamma (IFNgamma) (+874 T/A) polymorphism was also similar between the groups.
- Neither investigated polymorphism showed a significant association with idiopathic bronchiectasis susceptibility.
Conclusions:
- The studied CXCR-1 and IFNgamma gene polymorphisms are not associated with susceptibility to idiopathic bronchiectasis.
- Further research may be needed to explore other genetic factors or immune pathways in this condition.
Related Concept Videos
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
02:32Exon Recombination
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Exon shuffling follows “splice frame rules.” Each exon has three reading...
01:23Cystic Fibrosis: Pathogenesis
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:05Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...