Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue patterning in the developing mouse limb.

P Martin1

  • 1Department of Human Anatomy, Oxford University, United Kingdom.

The International Journal of Developmental Biology
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Listeria monocytogenes peritonitis: case report and literature review.

The American journal of gastroenterology·1992
Same author

Diarrhea among African children born to human immunodeficiency virus 1-infected mothers: clinical, microbiologic and epidemiologic features.

The Pediatric infectious disease journal·1992
Same author

Actin cables and epidermal movement in embryonic wound healing.

Nature·1992
Same author

Recurrence of hepatitis B and delta hepatitis after orthotopic liver transplantation.

Gut·1992
Same author

Characterization of a paired box- and homeobox-containing quail gene (Pax-QNR) expressed in the neuroretina.

Oncogene·1992
Same author

An early molecular component of the wound healing response in rat embryos--induction of c-fos protein in cells at the epidermal wound margin.

Mechanisms of development·1992
Same journal

Spatiotemporal dynamics of lineage-specific epithelial maturation in the developing mouse stomach.

The International journal of developmental biology·2026
Same journal

Dynein axonemal assembly factors (<i>dnaaf</i>) 5 and 9 are expressed in ciliated organs of zebrafish embryos.

The International journal of developmental biology·2026
Same journal

A chloroquine sensitivity gradient induces tissue regeneration and maintenance phenotypes in planarians.

The International journal of developmental biology·2026
Same journal

Sialylated glycoproteins and sialyltransferases involved in mesoderm-derived organ formation during embryogenesis.

The International journal of developmental biology·2026
Same journal

The <i>Hydra</i> FGF family - dispersed across the genome and expressed locally.

The International journal of developmental biology·2026
Same journal

Correction: Inhibition of COX2 impairs angiogenesis and causes vascular defects in developing zebrafish embryos.

The International journal of developmental biology·2025
See all related articles

This study details mouse limb development from E9.5 to E14.5, outlining tissue patterning and establishing standard developmental stages. It compares mouse limb development to chick, noting key differences in tissue formation and cell migration.

Area of Science:

  • Developmental Biology
  • Embryology
  • Comparative Anatomy

Background:

  • Limb development is a complex process crucial for vertebrate anatomy.
  • Understanding embryonic limb formation aids in identifying developmental abnormalities.

Purpose of the Study:

  • To establish a standardized staging system for mouse limb development.
  • To detail the spatiotemporal patterning of multiple tissue types during limb morphogenesis.
  • To compare mouse limb development with that of other vertebrates, particularly the chick.

Main Methods:

  • Utilized scanning electron microscopy and histological sections of mouse embryos.
  • Examined embryos at precise half-day intervals from embryonic day 9.5 (E9.5) to E14.5.
  • Employed MF20 antibody staining to identify early myogenic cells.

Related Experiment Videos

Main Results:

  • Defined standard stages for mouse limb development from E9.5 to E14.5.
  • Detailed the proximodistal skeletal patterning, nerve entry, muscle development, and epidermal maturation.
  • Observed differences in apical ectodermal ridge formation and myogenic cell migration compared to chick limb development.

Conclusions:

  • Mouse limb development follows a proximodistal pattern for skeletal elements.
  • Nerve and muscle patterns mature concurrently with skeletal development.
  • Key differences exist between mouse and chick limb development, including timing and cellular processes.