Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eosinophilic disorders in children.

Amy Wagelie-Steffen1, Seema S Aceves

  • 1Division of Allergy, Immunology, Children's Hospital of San Diego, 3020 Children's Way MC-5114, San Diego, CA 92123, USA.

Current Allergy and Asthma Reports
|October 10, 2006
PubMed
Summary

Pediatric eosinophilic disorders, including asthma and eosinophilic esophagitis, involve eosinophil-driven tissue damage. New biologic therapies offer hope, but understanding disease progression and treatment remains crucial.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial.

The lancet. Gastroenterology & hepatology·2026
Same author

Running out of air: Loss of hypoxia-inducible factor and CD73-dependent repair in eosinophilic esophagitis.

The Journal of allergy and clinical immunology·2026
Same author

Future of therapy and monitoring for eosinophilic esophagitis and eosinophilic gastrointestinal diseases.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025
Same author

Eosinophilic esophagitis: An allergy and immunology perspective on the updated guidelines.

The Journal of allergy and clinical immunology·2025
Same author

Usability of a Mobile Point-of-Care App for the Index of Severity for Eosinophilic Esophagitis.

Gastro hep advances·2025
Same author

Cutaneous ceramide synthesis is dysregulated in pediatric eosinophilic esophagitis.

The Journal of allergy and clinical immunology·2025

Area of Science:

  • Pediatric Allergy and Immunology
  • Gastroenterology
  • Hematology

Background:

  • Eosinophilia is a hallmark of various pediatric diseases, ranging from common atopic conditions like asthma to rarer disorders such as hypereosinophilic syndrome and eosinophilic gastrointestinal disorders.
  • Eosinophil activity in affected organs causes tissue damage, initiating repair processes that can lead to long-term structural and functional changes.

Purpose of the Study:

  • To review the current understanding of pediatric eosinophilic disorders.
  • To highlight recent advancements in therapeutic options.
  • To emphasize the ongoing need for research into pathogenesis, diagnosis, treatment, and natural history.

Main Methods:

  • Literature review of pediatric eosinophilic disorders.
  • Analysis of current treatment modalities, including biologic agents.
  • Discussion of disease mechanisms and clinical presentation.

Main Results:

  • Eosinophilic disorders are increasingly diagnosed in children.
  • Biologic agents like tyrosine kinase inhibitors and anti-interleukin-5 show promise in treating specific eosinophilic conditions.
  • Significant knowledge gaps persist regarding optimal management and long-term outcomes.

Conclusions:

  • Pediatric eosinophilic disorders represent a significant clinical challenge.
  • Targeted therapies are emerging, but a comprehensive understanding is still developing.
  • Further research is essential to improve patient care and outcomes for these conditions.

Related Experiment Videos