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Updated: Jul 19, 2026
Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
Published on: January 6, 2012
Presence of hydrosalpinx correlated to endometrial inflammatory response in vivo
Alan B Copperman1, Valerie Wells, Martha Luna
1Mount Sinai School of Medicine, Department of Obstetrics and Gynecology, New York, New York, USA. acopperman@rmany.com
Objective:
To evaluate and compare the inflammatory response and mediators in the endometrium of patients with hydrosalpinges compared with normal controls.
Design:
Retrospective case-control study.
Setting:
Urban medical center.
Patient(S) And Intervention(S):
Hysterectomy samples were identified as being affected by hydrosalpinx or salpingitis (n = 30) and were age-matched with control samples (n = 30).
Interventions:
Fallopian tube and endometrial slides were analyzed for leukocytes and immunohistochemical techniques performed for cytokines (interleukin-2 [IL-2]).
Main Outcome Measure(S):
Evaluate and compare the endometrial inflammatory response (leukocytes and cytokines) from samples affected and non-affected by hydrosalpinx and salpingitis.
Result(S):
Examination of tubal and endometrial slides with hydrosalpinx demonstrated a statistically significant increase in the number of overall inflammatory cells. High-intensity immunohistochemical staining for IL-2 was demonstrated in 7.4% of controls versus 65% of cases.
Conclusion(S):
A defined, identifiable, local response to hydrosalpingeal fluid has been demonstrated in the endometrium. This response consists of statistically significant elevations of leukocytes and IL-2. An inflammatory endometrial response may be an independent contributor to the decreased reproductive outcome observed in patients with hydrosalpinges.
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